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    • 专利摘要:
    antimicrobial compositions cationic active ingredients and quaternary sugar derived surfactants. The antimicrobial composition of the present invention comprises a cationic active ingredient, a quaternized sugar derivative surfactant and an optional foam reinforcing surfactant. The present antimicrobial compositions are free of the triclosane antimicrobial agent (i.e. 2,4,4'-trichloro-2'-hydroxydiphenyl ether), have a high deadly activity in a short time, provide stable abundant foam and exhibit better compatibility. with the tissue (eg skin) as defined by a complete in vitro toxicological assessment method.
    公开号:BR112013006096B1
    申请号:R112013006096-4
    申请日:2011-09-22
    公开日:2018-07-10
    发明作者:E. Pedersen Daniel；R. Eder Angela；A. Hodge Charles
    申请人:Ecolab Usa Inc.；
    IPC主号:
    专利说明:

    (54) Title: ANTIMICROBIAL COMPOSITIONS CONTAINING ACTIVE INGREDIENTS CATHONIC AND SURFACTANTS DERIVED FROM QUATERNARY SUGAR (51) Int.CI .: A61K 8/40; A01N 25/16; A01N 25/30; A01N 33/12; A01N 47/44; A61K 8/41; A61K 8/43; A61K 8/60; 1/62 C11D; 1/66 C11D; 1/75 C11D; 1/115 C11D; 1/11 C11D; 1/11 C11D; C11D 3/22; C11D 3/30; A61Q 17/00; A61Q 19/10 (30) Unionist Priority: 22/09/2010 US 61 / 385,341 (73) Holder (s): ECOLAB USA INC.
    (72) Inventor (s): DANIEL E. PEDERSEN; ANGELA R. EDER; CHARLES A. HODGE
    1/33 “ANTIMICROBIAL COMPOSITIONS CONTAINING INKEDIC ACTIVE INGREDIENTS AND SURFACES DERIVED FROM QUATERNARY SUGAR”
    FIELD OF THE INVENTION [001] The present invention is intended for antimicrobial compositions, such as personal care compositions, having improved antimicrobial efficacy and high foaming attributes. More particularly, the present invention relates to antimicrobial compositions exhibiting the antimicrobial efficacy of cationic active ingredients and a polyquaternary functionalized alkyl polyglycoside or a quaternary functionalized alkyl polyglycoside with optional properties of a broad spectrum of antimicrobial effectiveness, highly foaming and reduced irritation to mammalian tissues .
    BACKGROUND OF THE INVENTION [002] Antimicrobial personal care compositions are known in the art. Antimicrobial cleaning compositions that are typically used to clean the skin and to destroy bacteria and other microorganisms present on the skin, especially in the user's hands, arms and face, are especially useful.
    [003] Antimicrobial compositions are used, for example, in the healthcare industry; long-term care, hospital and health / exercise facilities; food service industry, meat processing industry and in the private sector by individual consumers. The widespread use of antimicrobial compositions indicates the importance that consumers place on the control of bacteria and other populations of microorganisms on the skin. It is important, however, that antimicrobial populations provide a substantial and wide spectrum reduction in microorganism populations quickly and without toxicity problems associated with skin irritation and toxicity.
    [004] In particular, antimicrobial cleaning compositions
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    2/33 typically contain an active antimicrobial agent, an anionic surfactant for cleaning and foaming, skin conditioning agents for cosmetic and coloring effects, perfumes and optional thickening agents, such as clays, polymers, cellulosic derivatives or colloids, for effects esthetics, all of this in an aqueous vehicle.
    [005] Several different classes of antimicrobial agents have been used in antimicrobial cleaning compositions. These include active ingredients selected from the following classes: phenolic compounds, carbanalide compounds, lower alcohols, surface active agent halogens and carboxylic acids. Each of these classes has its own advantages and challenges. Examples of specific antimicrobial agents include PCMX (para-chloromethaxylenol), triclosan, triclocarban, benzyl alcohol, quaternary ammonium compounds (QAC), iodine and iodine and biguanide complexes (for example, chlorhexidine diglyconate). Currently, triclosan is the dominant antimicrobial active ingredient in the dermal cleanser market.
    [006] Although there is a growing consumer demand for products that have activity against bacteria and other microorganisms, there is an even greater demand to meet consumer expectations regarding their levels of concern with certain biocides such as triclocarban and triclosane.
    [007] Triclosan is disadvantaged as an antimicrobial agent due to environmental persistence and health concerns due to the possible formation of intermediate and / or environmental products. Thus, there is a need for an effective antimicrobial personal care composition that is substantially free of biocides such as triclocarban and triclosan, yet still provides a high level of foaming desired by consumers and is gentle on the skin. The present invention is intended for such antimicrobial compositions.
    [008] The aforementioned disadvantages of current compositions
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    3/33 antimicrobials are addressed by modalities of the present invention and will be understood by reading and studying the following specification. The following summary is by way of example and not by limitation. It is provided only to assist the reader in understanding some aspects of the invention.
    SUMMARY OF THE INVENTION [009] The summary of the invention is intended to introduce the reader to several exemplary aspects of the invention. Particular aspects of the invention are shown in other sections here below, and the invention is set out in the appended claims which, by themselves, limit its scope.
    [010] In accordance with an exemplary embodiment of the present invention, an antimicrobial composition which exhibits rapid efficacy and forming attributes and is highly foamed. The antimicrobial composition comprises a cationic active ingredient, a surfactant derived from quaternized sugar, a foam reinforcing surfactant that can include nonionic surfactants, amphoteric surfactants, cationic surfactants, anionic surfactants and water. The present antimicrobial compositions are free of the antimicrobial agent triclosan (ie 2,4,4'-trichloro-2'-hydroxydiphenyl ether), have a high deadly activity in a short period of time, provide abundant stable foam and can, optionally , contain ingredients to increase skin compatibility and health.
    [011] Accordingly, an aspect of the present invention is to provide an antimicrobial composition to reduce the microbial population in the dermal tissue, the antimicrobial composition comprising: (a) about 0.3% by weight to about 6.0% by weight active cationic compounds; (b) about 0.1% by weight to about 18% by weight of a surfactant derived from quaternized sugar; (c) about 0.1% by weight to about 40% by weight of a foam reinforcing surfactant; (d) about 1% by weight to about 25% by weight of dermal adjuvants and (e) water or other suitable diluent.
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    4/33 [012] Additionally, an aspect of the present invention is to provide an antimicrobial composition to reduce the microbial population in the dermal tissue, where the composition has a ratio in relative weight of the cationic active compound to the quaternized sugar surfactant to the surfactant foam reinforcer from about 1: 0.2: 0.2 to about 1: 3: 8.
    [013] Another aspect of the present invention is to provide an antimicrobial composition to reduce the microbial population in dermal tissue that is stable and has a pH of about 4.0 to about 9.0. The present composition also has excellent aesthetic properties, such as abundant foaming and foam stability, and can optionally contain ingredients to increase skin compatibility and skin health. In addition, the composition may have reduced tissue irritation potential.
    [014] Another aspect of the present invention is to provide products for personal use based on an antimicrobial composition of the present invention, for example, a skin cleanser, a surgical mop, a hand sanitizing gel, a disinfectant, an antiseptic lotion. and the like.
    [015] Another aspect of the present invention is to provide a method of reducing populations of gram positive and / or gram negative bacteria in mammalian tissue, including human tissue, by contacting tissue, such as skin, with a composition of the present invention for a period of time sufficient, such as about 30 seconds to 5 minutes, to reduce the bacterial level to a desired level. The antimicrobial efficacy is applicable to viral and fungal organisms, as well as gram-positive and gram-negative bacteria.
    [016] Although various embodiments are disclosed, still other embodiments of the present invention will become apparent to those skilled in the art from the detailed description below, which shows and describes illustrative embodiments of the invention. Therefore, the detailed description should be considered as
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    5/33 illustrative and not restrictive.
    BRIEF DESCRIPTION OF THE DRAWINGS [017] FIGURE 1 illustrates a graph showing the results of the effectiveness tests after a 30 second exposure time of three different cationic active ingredients, specifically, 0.5% quat (benzalkonium chloride), CHG 2 % (chlorhexidine gluconate) and PHMB 1% (polyhexamethylenebiguanide) in a representative surfactant system.
    [018] FIGURE 2 illustrates a graph showing the results of the efficacy test against S. aureus and Escherichia colic bacteria with increased concentrations of surfactants derived from quaternary sugar, specifically (poly) trimonium-hydroxypropylcocoglycoside chloride. The type and amount of cationic active ingredient (0.5% ADBAC) and foam reinforcing surfactant (1.95% alkyldimethylamine oxide) were kept constant.
    [019] FIGURE 3 illustrates a graph showing the results of the effectiveness test with increased concentrations of foam reinforcing surfactants, specifically, amine oxide. The type and amount of cationic active ingredient (ADBAC 0.5%) and the surfactant derived from quaternary sugar ((poly) trimonium hydroxypopylcocoglycoside chloride 1.25%) were kept constant.
    [020] FIGURE 4 illustrates the skin irritation (softness) of the preferred modality for an antimicrobial skin cleanser for four commercially available antimicrobial soaps.
    [021] FIGURE 5 illustrates the foam profile of the preferred modality for an antimicrobial skin cleanser for three commercially available antimicrobial soaps.
    [022] FIGURE 6 illustrates the efficacy against S. aureus and Escherichia coli bacteria after a 30-second exposure to an active cationic component together with quaternary sugar derivative surfactants, kept constant at 1.25% and a
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    6/33 n-alkyl (C12-16) dimethylamine oxide foam reinforcing surfactant.
    [023] FIGURE 7 illustrates the foam stiffness of the preferred mode for an antimicrobial skin cleanser for two commercially available antimicrobial soaps with cationic active compounds.
    DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS [024] In addition to the examples of manipulation, or where otherwise indicated, all numbers expressing quantities of ingredients or reaction conditions used herein should be considered to be modified in all instances by the term about.
    [025] As used in this document, weight percentage, weight% and the like are synonyms that refer to the concentration of a substance as the weight of that substance divided by the total weight of the composition and multiplied by 100.
    [026] As used in this document, the term about modifying the amount of an ingredient in the compositions of the invention or used in the methods of the invention refers to the variation in the numerical quantity that can occur, for example, through typical measurement and measurement procedures. manipulation of liquids used to make concentrates or solutions for use in the real world; through inadvertent error in these processes; through differences in the manufacture, source or purity of the ingredients used to make the compositions or perform the methods; and the like. The term about also encompasses values that differ due to different equilibrium conditions for a composition resulting from a particular initial mixture. The claims, whether modified or not by the term "about", include equivalent amounts.
    [027] As used in this document, the term "cationic active substance" is defined as the ingredient that provides deadly antimicrobial activity.
    [028] As used in this document, the term “active care substance
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    7/33 skin ”is defined as the ingredient or ingredients that improve (m) or maintain / maintain the health of the dermal barrier.
    [029] The term alkyl refers to a monovalent straight or branched chain hydrocarbon radical with a specified number of carbon atoms. As used herein, alkyl refers to a straight or branched C6-C18 carbon chain.
    [030] The term microbial or microbial population refers to bacteria, fungi, yeasts or the viral population or combinations thereof, or any mixture thereof, in a laboratory setting or in the natural environment.
    [031] The term "surfactant" or "surface active agent" refers to an organic chemical substance that, when added to a liquid, changes the properties of that liquid on a surface or interface.
    [032] Cleaning means performing or assisting in removing dirt, whitening, reducing the microbial population, washing or a combination of these.
    [033] As used in this document, the term substantially exempt refers to compositions that are completely free from the component or having a very small amount of the component so that it does not affect the effectiveness of the composition. The component can be present as an impurity or a contaminant and must be less than 0.5% by weight. In another embodiment, the amount of the component is less than 0.1% by weight and, in yet another embodiment, the amount of the component is less than 0.01% by weight.
    [034] It should be noted that, as used in this specification and in the appended claims, the forms of the singular one, one and the include the references in the plural, unless the content clearly states otherwise. Thus, for example, a composition containing a compound includes a mixture of two or more compounds. It should also be noted that the term or is generally used in this sense, including and / or, unless the content
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    8/33 clearly state otherwise.
    [035] The terms "active" or "percentage assets" or "percentage by weight of assets" or "concentration of assets" are used interchangeably in this document and refer to the concentration of those ingredients involved in cleaning expressed as a percentage less inert ingredients, such as water or salts.
    [036] As used in this document, the terms "triclosan-free" or "triclosan-free" refer to a composition, mixture or ingredients that do not contain triclosane (2,4,4'-trichloro-2'-hydroxy ether -diphenyl) or compounds containing triclosan or so that it has not been added. If triclosan or compounds containing triclosan are present through the contamination of a composition, mixture or ingredients, the amount thereof must be less than 0.5% by weight. In another embodiment, the amount is less than 0.1% by weight and, in yet another modality, the amount is less than 0.01% by weight.
    [037] Antimicrobial Compositions Containing Quaternized Sugar-Derived Cationic and Surfactant Active Compounds [038] The present invention relates to an antimicrobial composition that exhibits rapid efficacy and foaming attributes in large quantities. The antimicrobial composition comprises a cationic active ingredient, a surfactant derived from quaternized sugar, a foam reinforcing surfactant that can include anionic surfactants, nonionic surfactants, amphoteric surfactants or cationic surfactants and water. The present antimicrobial compositions are free of the antimicrobial agent triclosan (ie 2,4,4'-trichloro-2'-hydroxydiphenyl ether), have a high deadly activity in a short period of time, provide abundant stable foam and can, optionally , contain ingredients to increase skin compatibility and skin health.
    [039] In one embodiment, an antimicrobial composition for reducing the microbial population in dermal tissue includes: (a) about 0.3% by weight to about
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    6.0 by weight of cationic assets; (b) about 0.1% by weight to about 18% by weight of a surfactant derived from quaternized sugar; (c) about 0.1% by weight to about 40% by weight of a foam reinforcing surfactant; (d) about 1% by weight to about 25% by weight of dermal adjuvants and (e) water or other suitable diluent. The relative weight ratio of cationic active ingredient to quaternized sugar surfactant to foam reinforcing surfactant is about 1: 0.2: 0.2 to about 1: 3: 8.
    [040] Another aspect of the present invention is to provide an antimicrobial composition to reduce the microbial population in dermal tissue that is stable and has a pH of about 5.0 to about 8.0. The present composition also unexpectedly has excellent aesthetic properties, such as abundant foaming and foam stability, and can optionally contain ingredients to increase skin compatibility and skin health. In addition, the composition may have reduced tissue irritation potential.
    [041] Another aspect of the present invention is to provide products for personal use based on an antimicrobial composition of the present invention, for example, a skin cleanser, a surgical mop, a hand sanitizing gel, a disinfectant and the like.
    [042] Another aspect of the present invention is to provide a method of reducing populations of gram positive and / or gram negative bacteria in mammalian tissue, including human tissue, by contacting tissue, such as skin, with a composition of the present invention for a period of time sufficient, such as about 30 seconds to 5 minutes, to reduce the bacterial level to a desired level.
    [043] The following non-limiting modalities of the present invention are exemplified.
    A.Cationic active substances [044] A cationic active substance is present in a composition
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    10/33 antimicrobial to reduce the microbial population in the dermal tissue of a mammal of the present invention by an amount from about 0.3% to about 6.0% by weight, and preferably from about 0.5% by weight to about 0.5% by weight of the composition.
    [045] The amount of antimicrobial agent in the composition is related to the final use of the composition, the amount of surfactant derived from quaternized sugar and foam reinforcing surfactant in the composition and the presence of optional ingredients in the composition. The amount of antimicrobial agent is sufficient to achieve microbial destruction in a short contact time, for example, 15 to 30 seconds.
    [046] Cationic active ingredients are an antimicrobial agent useful in the present invention. Cationic or cationically active ingredients are substances based on cationic portions centered on nitrogen with a net positive charge. The cationic or cationically active ingredients are selected from the group consisting of cationic polymers, cationic surfactants, cationic monomers, cationic silicon compounds, cationic derivatized protein hydrolysates and betaine with at least one cationic or cationically active group.
    [047] Suitable cationic active ingredients contain quaternary ammonium groups. Suitable cationic active ingredients especially include those of general formula:
    N (+) R 1 R 2 R 3 R 4 X (-) where R 1 , R 2 , R 3 and R 4 , independently of each other, represent alkyl groups, aliphatic groups, aromatic groups, alkoxy groups, polyoxyalkylene groups , alkylamido groups, hydroxyalkyl groups, aryl groups, H + ions, each with 1 to 22 carbon atoms, with the proviso that at least one of the groups R 1 , R 2 , R 3 and R 4 has at least eight atoms carbon and where X (-) represents an anion, for example, a halogen, acetate, phosphate, nitrate or alkyl sulfate,
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    11/33 preferably a chloride. Aliphatic groups can also contain crosslinking or other groups, for example, additional amino groups, in addition to carbon and hydrogen atoms.
    [048] Particular cationic active ingredients include, for example, but are not limited to, alkyldimethylbenzylammonium chloride (ADBAC), alkyldimethylethylbenzylammonium chloride, dialkyldimethylammonium chloride, benzethonium chloride, N, N-bis- (3aminopropyl) dodecylamine, glyconate chlorhexidine, PHMB (polyhexamethylenebiguanide), salt of a biguanide, a substituted biguanide derivative, an organic salt of a compound containing quaternary ammonium or an inorganic salt of a compound containing quaternary ammonium containing the compound or mixtures thereof.
    [049] According to an important feature of the present invention, an antimicrobial composition present is substantially free of triclosan. The phrase substantially free of triclosan is defined as meaning that the composition contains 0% to about 0.25% by weight, in total, of triclosane. In particular, triclosan can be present in an antimicrobial composition in a total amount of 0.25% or less, as a by-product or as a component of an ingredient in the composition, but triclosan is not intentionally introduced into the composition.
    [050] Triclosan is disadvantaged as an antimicrobial agent due to environmental and health concerns due to the possible formation of intermediate and / or environmental by-products.
    B. Surfactant derived from quaternized sugar [051] In addition to an antimicrobial agent, the present antimicrobial composition for reducing the microbial population in the dermal tissue of a mammal of the present invention also contains a surfactant derived from quaternized sugar. The surfactant derived from quaternized sugar is present in an amount of about 0.1% to about 18%, and preferably from about 0.25% to about
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    12.5% by weight of the composition.
    [052] The amount of surfactant derived from quaternized sugar in the composition is related to the amount of cationic active substance in the composition, the identity of the surfactant derived from quaternized sugar and the end use of the composition.
    [053] The surfactant derived from quaternized sugar is a quaternized alkyl polyglycoside or a polyquaternized alkyl polyglycoside, and the like.
    [054] In one embodiment, the antimicrobial composition of the present invention includes a polyquaternary functionalized alkyl polyglycoside, a cationic active ingredient, water and an optional foam reinforcing surfactant. The quaternary functionalized alkyl polyglycoside is a cationic surfactant naturally derived from alkyl polyglycosides and has a sugar structure. Polyquaternary alkyl polyglycosides have the following representative formula:
    : <
    HjC Ν '- «**.
    kHO -ç; —o,> ..... o „ x η
    p where R is an alkyl group having about 6 to 22 carbon atoms and n is an integer, ranging from 4 to 6. Examples of quaternary functionalized alkyl polyglycoside components that can be used in the cleaning compositions according to the present The invention includes those in which the alkyl R portion contains about 8 to about 12 carbon atoms. In a preferred embodiment, the quaternary functionalized alkyl polyglycoside contains mainly about 10 to 12 carbon atoms. Examples of polyquaternary functionalized alkyl polyglycosides useful in the cleaning compositions of the present invention include, but are not limited to: the Poly Suga® Quat series of functionalized alkyl polyglycosides
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    13/33 polyquaternaries, available from Colonial Chemical, Inc., located in South Pittsburg, TN.
    [055] In another embodiment, the antimicrobial composition of the present invention includes a quaternary functionalized alkyl polyglycoside, a cationic active ingredient, water and an optional foam reinforcing surfactant. The quaternary functionalized alkyl polyglycoside is a cationic surfactant naturally derived from alkyl polyglycosides and has a sugar structure. Quaternary functionalized alkylpolyglycosides have the following representative formula:
    where Ri is an alkyl group having from about 6 to about 22 carbon atoms and R2 is CH3 (CH2) n ', where n is an integer ranging from 0 to 21. Examples of suitable quaternary functionalized alkyl polyglycoside components that can be used in the cleaning compositions according to the present invention include those in which the R1 alkyl portion contains mainly about 10 to 12 carbon atoms, the group R2 is CH3 and n is the polymerization degree of 1-2. Other examples of a quaternary functionalized alkyl polyglycoside include, but are not limited to, the antifungal functionalized quaternary alkyl polyglycosides described in U.S. Patent Nos. 7,084,129 and 7,507,399, the disclosures of which are hereby incorporated by reference. Examples of commercially suitable quaternary functionalized alkyl polyglycosides useful in the cleaning compositions of the present invention include, but are not limited to: Suga Quat TM 1212 (mainly C12 quaternary functionalized alkyl polyglycoside), Suga Quat L 1210 (mainly C12 functionalized quaternary alkyl polyglycoside) and Suga Quat s
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    1218 (mainly C12 quaternary functionalized alkyl polyglycoside), available from Colonial Chemical, Inc., located in South Pittsburg, TN.
    C. Foam-reinforcing co-surfactant [056] In addition to an antimicrobial agent and a quaternized sugar-derived surfactant, the present antimicrobial composition for reducing the microbial population in the mammalian dermal tissue of the present invention also contains a foam-reinforcing surfactant. The foam reinforcing surfactant is present in an amount of about 0.02% to about 10.0% and, preferably, from about 2% to about 6%, by weight, of the composition.
    [057] The amount of foam reinforcing surfactant present in the composition is related to the amount of cationic active substance in the composition, the amount of surfactant derived from quaternized sugar in the composition and the identity of the foam reinforcing surfactant and the end use of the foam. composition.
    [058] The foam reinforcing cotensoative may comprise (a) non-ionic surfactants, (b) amphoteric surfactants, (c) cationic surfactants, (d) anionic surfactants and the like, or (e) mixtures thereof.
    Nonionic Foam Reinforcing Surfactant [059] Examples of nonionic foam reinforcing cotensoatives include, but are not limited to, alkylamine oxide, alkyl ether oxide, alkyl alcohol alkoxylates, aryl alcohol alkoxylates, substituted alcohol alkoxylates, non-ionic block copolymers , nonionic heteric copolymers, alkanolamides, substituted amides or polyethoxylated glycerol derivatives.
    [060] The antimicrobial composition may contain a nonionic surfactant component that includes a detergent amount of nonionic surfactant or a mixture of nonionic surfactants. Typically, a nonionic surfactant has a hydrophobic region, such as a long chain alkyl group or an alkylated aryl group, and a hydrophilic group comprising an ethoxy and / or other hydrophilic moieties.
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    As defined in this document, a non-ionic foam reinforcing cotensoactive ”has a hydrophobic region that has an alkyl group containing six to eighteen carbon atoms, and an average of one to about twenty ethoxy and / or propoxy moieties. Examples of non-ionic foam reinforcing cotensoatives include, but are not limited to, alkylamine oxide, alkyl ether oxide, alkyl alcohol alkoxylates, aryl alcohol alkoxylates, substituted alcohol alkoxylates, non-ionic block copolymers, non-ionic methyl copolymers, alkanolamides or esters of polyethoxylated glycerol, and mixtures thereof.
    [061] Several other non-ionic surfactants are disclosed in McCutcheon's Detergents and Emulsifiers, 1993 Annuals, published by McCutcheon Division, MC Publishing Co., Glen Rock, N.J., pp. 1-246 and 266-273; in the International Cosmetic Ingredient Dictionary, CTFA, Fourth Edition, Cosmetic, Toiletry and Fragrance Association, Washington, D.C. (1991) (hereinafter the CTFA dictionary) on pages 1-651; and the Cosmetic Ingredient Handbook, CTFA, First Edition, Cosmetic, Toiletry and Fragrance Association, Washington, DC (1988) (hereinafter the CTFA Manual), pages 86-94, each of which is incorporated into this document by reference .
    Amphoteric Foam Reinforcing Surfactant [062] The antimicrobial composition may contain an amphoteric surfactant component that includes a detergent amount of amphoteric surfactant or a mixture of amphoteric surfactants. Suitable amphoteric surfactants that can be used include, but are not limited to, imidiazolines and imidiazoline derivatives, isethionates, betaine derivatives, anfoacetate derivatives, propionates and mixtures thereof.
    Anionic Foam Reinforcing Surfactant [063] The antimicrobial composition may contain an anionic surfactant component that includes a detergent amount of an anionic surfactant or a
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    16/33 mixture of anionic surfactants. Anionic surfactants that can be used according to the invention include any anionic surfactant available in the cleaning industry. Suitable groups of anionic surfactants include sulfonates and sulfates. Suitable surfactants that can be provided in the anionic surfactant component include, but are not limited to, sarcosine derivatives, succinic acid derivatives, carboxylated alcohols, alkyl sulfate and alkylethyl sulfates, sulfonic acid derivatives, diphenyl sulfonate derivatives, alkyl aryl sulfonic acid derivatives, alkyl polyglycosidesulfates or sulfonates.
    Cationic Foam Reinforcing Surfactant [064] The antimicrobial composition may contain a cationic surfactant component that includes a detergent amount of cationic surfactant or a mixture of cationic surfactants. Cationic surfactants that can be used in the antimicrobial composition include, but are not limited to, quaternized polysaccharides, alkyl polysaccharides, alkoxylated amines, alkoxylated etherines, phospholipids, phospholipid derivatives and mixtures thereof.
    D. Vehicle [065] The vehicle of the present antimicrobial composition comprises water, propylene glycol, glycerols, alcohols or mixtures thereof. It should be noted that the water can be supplied as deionized water or softened water. The water supplied as part of the concentrate can be relatively free of hardness. It is expected that the water can be deionized to remove some of the dissolved solids. That is, the concentrate can be formulated with water that includes dissolved solids, and it can be formulated with water that can be characterized as hard water.
    [066] The antimicrobial composition of the present invention does not depend on a low pH or a high pH to provide a rapid reduction in microbial populations.
    [067] The antimicrobial populations of the present invention have a pH of
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    17/33 about 5.0 to about 8.0. Within this pH range, the present compositions effectively reduce microbial populations and are acceptable to the consumer, that is, they are gentle on the skin, are stable from the point of view of phase and generate abundantly stable foam.
    E. Additional Functional Materials [068] The antimicrobial composition may include additional components or agents, such as additional functional materials. As such, in some embodiments, the antimicrobial composition including the cationic active ingredients and quaternary sugar derivatives can provide a large amount, or even the entire total weight of the antimicrobial composition, for example, in modalities having little or no additional functional material placed. in that. Functional materials provide desired properties and functionality to the antimicrobial composition. For the purposes of this application, the term "functional materials" includes a material that, when dispersed or dissolved in a use and / or concentrated solution, such as an aqueous solution, provides a beneficial property in a particular use. The antimicrobial composition containing the cationic active ingredients and the quaternized sugar-derived surfactants may optionally contain other disinfectants, sanitizers, dyes, thickening agents or gelling agents and perfumes. Some particular examples of functional materials are discussed in more detail below, but it should be understood by persons skilled in the art and third parties that the particular materials discussed are given by way of example only, and that a wide variety of other functional materials can be used. For example, the functional material discussed below may refer to materials used in disinfection and / or cleaning applications, but it should be understood that other modalities may include functional materials for use in other applications.
    Dyes and Fragrances [069] Various dyes, odorants including perfumes and other agents
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    18/33 aesthetic improvements that are compatible with the chemistry of the invention can also be included in the antimicrobial composition.
    [070] Fragrances or perfumes that may be included in the compositions include, for example, terpenoids such as citronelol, aldehydes such as cinnamaldehyde, a jasmine such as CIS-jasmine or jasmal, vanillin and the like.
    Adjuvants [071] The present composition can also include several adjuvants. In one embodiment, adjuvants are present in an amount of about 1% to about 25%, and preferably about 1% to about 15%, by weight, of the composition, specifically, the antimicrobial composition can include glycerin, sorbitol, esters, polyquats, glycols, preservatives, chelators, pH additives, pigments or dyes, among any of a variety of other constituents that can be added to the composition. Such adjuvants can be pre-formulated with the present composition or added to the system simultaneously, or even after the addition of the present composition. The antimicrobial composition can also contain any number of other constituents, as required by the application, which are known and which can facilitate the activity of the present invention.
    Modalities of the Present Invention [072] The antimicrobial composition of the present invention has a broad spectrum of antimicrobial efficacy, great foaming and less irritation to mammalian tissues. Exemplary compositions are provided in the following tables.
    Antimicrobial skin cleanser
    Table 1 - Exemplary composition of Antimicrobial Skin Wash
    Expressed as Weight Percent)
    Antimicrobial Dermal Wash (pH 5.0-6.7) Ingredient Example Preferred mode (% w / w) Most preferred modality (% w / w)
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    Limitinf-rior Limitsupposerior Limitbottom Limithigher Cationic active ingredient Quaternary Ammonium Compound (QAC) [Alkyldimethylbenzylammonium chloride (ADBAC)] 0.4 1.5 0.5 1.0 Surfactant derived from quaternized sugar Quaternary functionalized alkylpolyglycoside or polyquaternary functionalized alkylpolyglycoside 0.1 4.5 0.25 2.5 Foam Reinforcing Surfactant Dimethylamine oxide; alkylpolyglycoside 0.1 12.0 1.0 5.0 Adjuvants(Dermal) Glycerin, sorbitol, esters, polyquats, glycols, preservative 1.0 25.0 2.0 10.0
    Table 2 - Exemplary composition of Antimicrobial Skin Wash
    Expressed as a Weight Ratio)
    Antimicrobial Dermal Wash (pH 5.0-6.7) Ingredient Example Preferred mode (weight ratio) Most preferred mode (weight ratio) Limitbottom Limithigher Limitinf-rior Limithigher Cationic active ingredient Quaternary Ammonium Compound (QAC) [Alkyldimethylbenzylammonium chloride (ADBAC)] 1.0 1.0 1.0 1.0 Surfactant derived from quaternized sugar Quaternary functionalized alkylpolyglycoside or polyquaternary functionalized alkylpolyglycoside 0.25 3.0 0.5 2.5 Foam Reinforcing Surfactant Dimethylamine oxide; alkyl-polyglycoside 0.25 8.0 2.0 5.0 Adjuvants(Dermal) Glycerin, sorbitol, esters, polyquats, preservative 2.5 16.0 4.0 10.0
    Table 3 - Exemplary composition of Skin Wash (Expressed as
    Weight Percent)
    Cleanser for the skin (pH 5.5-7.5) | Ingredient Example Preferred mode (% w / w) Most preferred modality (% w / w) Limit Limit Limitbottom Limithigher
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    inf-rior supposerior Cationic active ingredient Quaternary Ammonium Compound (QAC) [Alkyldimethylbenzylammonium chloride (ADBAC)] 0.3 5.0 0.5 4.0 Surfactant derived from quaternized sugar Quaternary functionalized alkylpolyglycoside or polyquaternary functionalized alkylpolyglycoside 0.1 15.0 0.25 10.0 Foam Reinforcing Surfactant Dimethylamine oxide; alkylpolyglycoside 0.1 40.0 2.0 20.0 Adjuvants(Dermal) Glycerin, sorbitol, esters, polyquats, preservative 1.0 25.0 1.75 15.0
    Table 4 - Exemplary Skin Wash Composition (Expressed as
    Weight Ratio)
    Skin cleanser (pH 5.5-7.5) Ingredient Example Preferred mode (% w / w) Most preferred modality (% w / w) Inferior limit Limitsupposerior Limitinf-rior Limitsupposerior Cationic active ingredient Quaternary Ammonium Compound (QAC) [Alkyldimethylbenzylammonium chloride (ADBAC)] 1.0 1.0 1.0 1.0 Surfactant derived from quaternized sugar Quaternary functionalized alkylpolyglycoside or polyquaternary functionalized alkylpolyglycoside 0.3 3.0 0.5 2.5 Foam Reinforcing Surfactant Dimethylamine oxide; alkyl-polyglycoside 0.3 8.0 1.0 5.0 Adjuvants(Dermal) Glycerin, sorbitol, esters, polyquats, preservative 3.3 5.0 3.5 3.75
    Table 5 - Exemplary composition of surgical pad (Expressed in weight)
    Surgical pad (pH 5.5-7.5) Ingredient Example Preferred mode (% w / w) Most preferred modality (% w / w) Limitinf-rior Limitsupposerior Limitinf-rior Limithigher
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    Cationic active ingredient Chlorhexidine gluconate (CHG) 1 6.0 1.5 5.0 Surfactant derived from quaternized sugar Quaternary functionalized alkylpolyglycoside or polyquaternary functionalized alkylpolyglycoside 0.2 18.0 0.6 12.5 Foam Reinforcing Surfactant Dimethylamine oxide; alkylpolyglycoside 0.2 36.0 1.5 25.0 Adjuvants(Dermal) Glycerin, sorbitol, esters, polyquats, preservative 1.0 25.0 2.0 10.0
    Table 6 - Exemplary composition of surgical pad (Expressed as weight ratio)
    Surgical mop ico (pH 5.5-7.5) Ingredient Example Preferred mode (% w / w) Most preferred modality (% w / w) Limitbottom Limitsupposerior Limitinf-rior Limitsupposerior Cationic active ingredient Chlorhexidine gluconate (CHG) 1.0 1.0 1.0 1.0 Surfactant derived from quaternized sugar Quaternary functionalized alkylpolyglycoside or polyquaternary functionalized alkylpolyglycoside 0.2 3.0 0.4 2.5 Foam Reinforcing Surfactant Dimethylamine oxide; alkylpolyglycoside 0.2 6.0 1.0 5.0 Adjuvants(Dermal) Glycerin, sorbitol, esters, polyquats, preservative 1.0 4.2 1.3 2.0
    [073] The formula can be available ready to use or as a concentrate that could be further diluted to the proper use concentration with water, either manually or by suitable equipment or an apparatus. The concentrate composition of the present invention can be provided as a solid, liquid, gel or a combination thereof. In one embodiment, the cleaning compositions can be provided as a concentrate, so that the cleaning composition is substantially free of any added water or the concentrate
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    22/33 may contain a nominal amount of water. The concentrate can be formulated without water or it can be supplied with a relatively small amount of water in order to reduce the cost of transporting the concentrate. For example, the concentrate of the composition can be supplied as a capsule or pellet of compacted, solid, or loose powder, whether it is contained by a water-soluble material or not. In the case of supplying the capsule or pellet of the composition in a material, the capsule or pellet can be introduced into a volume of water, and if present, the water-soluble material can solubilize, degrade or disperse to allow contact of the concentrate of the composition with the water. For the purposes of disclosure, the terms capsule and pellet ”are used for exemplary purposes and are not intended to limit the mode of administration of the invention to a specific format.
    [074] When supplied as a liquid concentrated composition, the concentrate can be diluted using dispensing equipment using vacuum cleaners, peristaltic pumps, gear pumps, mass flow meters and the like. This type of liquid concentrate can also be administered in flasks, jars, dosing flasks, flasks with dosing caps and the like. The concentrated liquid composition can be filled into a multi-chamber cartridge insert which is then placed in a spray bottle or other delivery device filled with a pre-measured amount of water.
    [075] In yet another embodiment, the concentrated composition can be supplied in a solid form that resists crumbling or other degradation until it is placed in a container. Such a container can be filled with water before placing the composition concentrate in the container or it can be filled with water after the composition concentrate is placed in the container. In any case, the composition of the solid concentrate dissolves, solubilizes or otherwise disintegrates upon contact with water. In a particular embodiment, the solid concentrated composition dissolves rapidly, thereby allowing the
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    23/33 concentrated composition becomes a use composition and still allowing the end user to apply the composition to a surface that needs cleaning. When the cleaning composition is provided as a solid, the compositions provided herein can be changed to solidify the cleaning composition by any means known in the art. For example, the amount of water can be reduced or additional ingredients can be added to the cleaning composition, such as a solidifying agent.
    [076] In another embodiment, the solid concentrated composition can be diluted through the dispensing equipment, whereby water is sprayed on the solid block to form the solution for use. The flow of water is released at a relatively constant rate, using mechanical, electrical or hydraulic controls, and the like. The solid concentrated composition can also be diluted using the dispensing equipment, through which water flows around the solid block, creating a solution for use as the solid concentrate dissolves. The solid concentrated composition can also be diluted using pellet, tablet, powder and paste dispensers, and the like.
    EXAMPLES [077] The present invention is more particularly described in the examples below which are intended to be illustrative only, since various modifications and variations in the scope of the present invention will be apparent to those skilled in the art. Unless otherwise stated, all parts, percentages and ratios reported in the examples below are by weight, and all reagents used in the examples have been obtained, or are available, from the chemical suppliers described below or may be synthesized by conventional techniques.
    [078] Materials used in the described modalities include, but are not limited to: stearyldimony chloride-hydroxypropyl urylglycosides, chloride
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    24/33 hydroxypyropyltrimonium cocoglycosides, hydroxypropyltrimonium chloride laurylglycosides, hydroxypropyldecylglycosides (poly) lauryldimony chloride, hydroxypropyldecylglycosides (poly) stearyldimony chloride, hydroxypropylcocoglycoside (poly) trimonium chloride.
    [079] The following methods were used in preparing and testing the examples:
    Antimicrobial and microbial efficacy:
    (a) Determination of neutralization activity time: The activity of antimicrobial compositions was measured by the neutralization time method [ASTM E 2315 Standard Guide for Assessment of Antimicrobial Activity Using a Time Kill Procedure], whereby the survival of challenged organisms exposed to an antimicrobial test composition is deterred by time. In this test, a diluted aliquot of the composition is brought into contact with a known population of test bacteria for a specified period of time at a specified temperature. The test composition is neutralized at the end of the time period, which stops the composition's antimicrobial activity. The percentage or, alternatively, the log of the reduction of the original bacterial population is calculated. In general, the neutralization time method is known to those skilled in the art. In addition, comparative data on the foam profile of the representative systems are shown.
    (b) The composition can be tested at any concentration from 0 to 100%. The choice of which concentration should be used is at the discretion of the investigator, and appropriate concentrations are readily determined by those skilled in the art. All tests, if performed in triplicate, have the results combined and the average log reduction is reported.
    (c) The choice of the contact time period is also at the discretion of the investigator. Any time period of contact can be chosen. Contact times
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    Typical 25/33 range from 15 seconds to 5 minutes, with 30 seconds and 1 minute being typical contact times. The contact temperature can also be any temperature, usually room temperature, or about 25 degrees Celsius.
    (d) The microbial suspension, or test inoculum, is prepared by culturing a microbial culture in any appropriate solid medium (for example, agar). The microbial population is then washed off the agar with sterile physiological saline and the population of the microbial suspension is adjusted to about 10 colony-forming units per milliliter (CFU / mL).
    (e) The table below lists the microbial test cultures used in the following tests and includes the name of the bacterium, the ATCC identification number (American Type Culture Collection) and the abbreviation the name of the organism used below.
    Name of the organization # ATCC Abbreviation S. aureusylococcus 6538 S. aureus Escherichia coli 112229 E. coli
    [080] S. aureus is a gram positive bacterium, whereas E. coli is a gram negative bacterium.
    [081] The logarithm of the reduction is calculated using the formula:
    Logarithm of reduction = log10 (control numbers) - log10 (survivors of the test sample).
    Determination of Foam Height [082] The height of the foam was determined with the following process steps:
    1. Prepare a 1% solution of the product in cereal water 5.
    2. Pour 150 mL of the solution into a mixer.
    3. Mix at medium speed for 10 seconds.
    4. Pour into a 1000 mL beaker and measure the height of the foam.
    5. Measure the height of the foam in 3 and 5 minutes.
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    Determination of Foam Stability [083] Foam stability was determined using the difference between foam / air interference and the foam / aqueous interface 5 minutes after pouring a 1% solution into a 1000 mL beaker.
    Determination of in vitro irritation [084] In vitro irritation was assessed by an external test device using the EPI-200 EpiDerm MTT ET-50 protocol from Matek Corporation.
    [085] The test consists of a topical exposure of the pure test chemical compound to a model of reconstructed human epidermis (RhE) followed by a cell viability test. Cell viability is measured by converting MTT dehydrogenase [(3,4,5-dimethylthiazol-2-yl bromide) 2,5-diphenyltetrazolium] present in the cell's mitochondria to a formazan blue salt that is quantitatively measured after tissue extraction. Reducing the viability of tissues exposed to chemicals compared to negative controls (treated with water) is used to predict the potential for skin irritation.
    [086] EpiDerm tissues are conditioned by incubation to release compounds related to transport stress and fragments overnight. After pre-incubation, tissues are topically exposed to test chemical compounds for 60 minutes. Preferably, three tissues are used per test chemical (TC) and for positive control (PC) and negative control (NC). The fabrics are then thoroughly washed, marked to remove test substances and transferred to fresh media. The tissues are incubated for 42 hours. After that, the MTT assay is performed by transferring the tissues to 24-well plates containing MTT medium (1 mg / mL) after an MTT incubation for 3 h, the blue formazan salt formed by the cellular mitochondria is extracted with 2, 0 ml / isopropanol tissue and the optical density of the extracted formazan is determined using a spectrophotometer at 570 nm. Relative cell viability is
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    27/33 calculated for each tissue as the% of the mean of the negative control tissues. The skin irritation potential of the test material is predicted if the remaining relative cell viability is less than 50%.
    Determination of Foam Strength [087] Foam strength was determined by measuring 65 grams of the test product in a mixer and mixing for about 10 seconds at medium speed. Then, the test solution was poured into a cylinder and a plastic ball was placed in the test solution and timed how many seconds it took for the plastic ball to descend from a predetermined first level to a second predetermined level. determined, for example, from the 100 mL mark on the cylinder to the 40 mL mark on the cylinder.
    [088] The following figures demonstrate efficacy data for the present antimicrobial composition using various cationic active ingredients, quaternary sugar derivative surfactants and optional foam reinforcing surfactants.
    [089] Table 7 and Figure 1 (cationic active ingredient elimination logarithm): the following figures illustrate the effectiveness after a 30 second exposure time of three different cationic active ingredients, specifically, 0.5% quat ( benzalkonium chloride), 2% CHG (chlorhexidine gluconate) and 1% PHMB (polyhexamethylenebiguanide) in a representative surfactant system.
    [090] Table 7 illustrates the formulas for the three cationic active ingredient systems tested. Both the quaternary sugar-derived surfactant and the foam-reinforcing surfactant were kept constant and only the cationic active ingredient was modified between the three tests performed. The results are illustrated in Figure 1 .___
    Active Ingredient System Ingredients Level (% w / w) Quaternary ammonium compound (Quat) Active ingredient 0.5 Surfactant derived from quaternized sugar 1.25
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    Foam Reinforcing Agent 1.95 Chlorhexidine gluconate (CHG) Active ingredient 2.0 Surfactant derived from quaternized sugar 1.25 Foam Reinforcing Agent 1.95 Polyhexamethylenebiguanide (PHMB) Active ingredient 1.0 Surfactant derived from quaternized sugar 1.25 Foam Reinforcing Agent 1.95
    TABLE 7 [091] As illustrated in Figure 1, all three cationic active ingredients had high deadly activity against S. aureus and E. coli bacteria in an exposure time of 30 seconds.
    [092] Table 8 and Figure 2 (logarithm of elimination of quaternary sugar-derived surfactants): The Applicants then tested the efficacy against S. aureus and E. coli bacteria with higher concentrations of quaternary sugar-derived surfactants. , specifically, (poly) trimonium hydroxypropyl cocoglycoside chloride. The type and amount of cationic active ingredient (ADBAC Quat 0.5%) and foam reinforcing surfactant (1.95% alkyldimethylamine oxide) were kept constant. Table 8 below illustrates the quantitative results of this test and Figure 2 illustrates the graphical results.
    Quaternized SubstanceActive Foam Logarithm of S. aureus E. coli logarithm Sugar derived surfactant (% w / w) Ingredient (% w / w) Reinforcing Agent (% w / w) Reduction Reduction 0.3 0.5 1.95 > 5.0 > 5.0 1.3 0.5 1.95 > 5.0 > 5.0 2.5 0.5 1.95 3.2 > 5.0
    TABLE 8 [093] As shown in Table 8 and Figure 2, the surfactant derived from quaternary sugar has a high deadly activity against S. aureus and E. coli bacteria after only 30 seconds of exposure. Additionally, the tolerance of the surfactant derived from quaternary sugar against bacteria is shown. Furthermore, it is
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    29/33 clearly illustrated that an increased concentration of surfactant derived from quaternary sugar maintains a good logarithm of bacteria elimination up to a 1 to 4 ratio of surfactant derived from quaternary sugar to cationic active ingredients.
    [094] Table 9 and Figure 3 (logarithm of elimination of foam reinforcing surfactants): Table 15 and Figure 3 illustrate the effectiveness with the highest concentrations of foam reinforcing surfactants, specifically, amine oxide. The type and quantity of cationic active ingredient (ADBAC Quat 0.5%) and the surfactant derived from quaternary sugar ((poly) trimonium hydroxypopylcocoglycoside chloride 1.25%) were kept constant. Table 9 below illustrates the results
    quantitative aspects of this test and the Figure 3 illustrates the graphical results. Foam Reinforcing Agent (% w / w) Active Substance (% w / w) Surfactant derived from quaternized sugar (% w / w) Logarithmic reduction of S. aureus E. coli logarithmic reduction 1.95 0.5 1.25 > 5.5 > 5.5 3.0 0.5 1.25 > 5.5 > 5.5 4.2 0.5 1.25 > 5.5 > 5.5
    TABLE 9 [095] As shown in Table 9 and Figure 3, the foam reinforcing surfactant has a high deadly activity against S. aureus and E. coli bacteria after only 30 seconds of exposure. Additionally, the tolerance of the foam reinforcing surfactant against bacteria is shown.
    [096] In addition, it is clearly illustrated that a wide range of foam reinforcing surfactants maintains a good bacteria elimination logarithm.
    [097] Figure 4 (Softness Index for an Antimicrobial Skin Cleaner Mode): Applicants tested the dermal irritation (smoothness) of the preferred modality for an antimicrobial skin cleaner, as shown in Table 12, for four commercially antimicrobial soaps available. Commercially available products A, C and D are available from Gojo Medicated, Akron, Ohio and commercially available product B is available from Dial, a
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    30/33 subsidiary of Henkel Corporation, Düsseldorf, Germany. As illustrated in Figure 4, the antimicrobial skin cleanser of the present invention has a relatively high softness index especially compared to commercially available antimicrobial hand soaps.
    [098] Figure 5 (Foam Profile for an Antimicrobial Skin Cleaner Mode): Applicants tested the foam profile of the preferred mode for an antimicrobial skin cleaner as shown in Table 12, for three commercially available antimicrobial soaps. As illustrated in Figure 6, the antimicrobial skin cleanser of the present invention has both good foam volume and foam stability compared to commercially available antimicrobial hand soaps.
    [099] Table 10 and Figure 6 (Efficacy of Cationic Active Substances Together with Surfactants Derived from Quaternary Sugar and Alkylldimethylamine Oxide): Applicants have tested the efficacy against S. aureus and E. coli bacteria with various surfactants derived from quaternary sugar, kept constant at 1.25%. The type and amount of cationic active ingredient (ADBAC Quat 0.5%) and foam reinforcing surfactant (1.95% alkyldimethylamine oxide) were kept constant.
    Surfactant derived from quaternized sugar (1.25% w / w) Active ingredient (%w / w) Foam Reinforcing Surfactant (% w / w) Logarithmic reduction of S. aureus E. coli logarithmic reduction (L8610) Lauryl dimethyl hydroxypropylcocoglycoside chloride 0.5 1.95 > 5.0 > 5.0 (L1210) Laurylthymone-hydroxypropillaurylglycoside chloride 0.5 1.95 > 5.0 > 5.0 (S1218) Stearyl chloride-dimonium-hydroxypropillaurylglico-sids 0.5 1.95 > 5.0 > 5.0 (TM8610) Hydroxypropyltrimony chloride cocoglycosides 0.5 1.95 > 5.0 > 5.0 (TM1212) Hydroxypropyltrimony chloride laurylglycosides 0.5 1.95 > 5.0 > 5.0
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    (L1010P) Hydroxypropyldecylglycoside (poly) lauryl chloridedaemon 0.5 1.95 > 5.0 > 5.0 (S1010P) (Poly) stearyldimony-hydroxypropyldecylglycosides chloride 0.5 1.95 > 5.0 > 5.0 (S1210P) (Poly) stearyldimony-hydroxypropillaurylglycoside chloride 0.5 1.95 > 5.0 > 5.0 (TM8610P) Chloride(poly) trimonium-hydroxypropylcocoglycosides 0.5 1.95 > 5.0 > 5.0
    TABLE 10 [0100] As shown in Table 10, a high elimination logarithm is maintained against the bacteria S. aureus and E. coli for quaternized sugar derivatives and polyquaternized sugar derivatives. The chain length of the quaternary sugar surfactant can be changed and still maintain high effectiveness. The graphic results of the test are illustrated in Figure 6.
    [0101] Table 11 and Figure 7 (Comparative Foam Stiffness): Applicants tested the foam stiffness of a modality of the current invention for use in dermal applications as shown below, in Table 11, in comparison with two commercially available products , Commercial Products E and F. Commercial Products E and F are dermal washes based on traditional anionic surfactants containing a cationic active substance. Commercial Product E is commercially available from Procter & Gamble, Cincinnati, Ohio and Commercial Product F is commercially available from Deb Group Limited, United Kingdom, England. The results of the foam stiffness test are illustrated in Figure 7. As shown in Figure 7, the stiffness of the dermal wash foam of the present invention is greater than the active dermal washes of commercially available cationic active substances with a traditional anionic surfactant base. .
    [0102] Foam Stiffness Formula of the Present Invention (pH 5.5-7.5):
    Component Percentage
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    by weight Water 91.7 Cationic active substance (ammonium compoundquaternary) 0.5 Surfactant derived from quaternized sugar 0.7 Foam Reinforcing Surfactant 4.1 Dermal adjuvants 3.0
    TABLE 11 [0103] Table 12 (Antimicrobial Effectiveness of a Dermal Cleaner of the Present Invention): Applicants tested the effectiveness of the dermal cleaner of the present invention by determining the logarithm of the reduction of gram positive and gram negative bacteria after 30 seconds of exposure.
    [0104] Cleanser for the skin (pH 5.5-7.5).
    Component Weight percentage range Water 7.5-99.3 Cationic active substance (ammoniumquaternary) 0.3-5 Surfactant derived from quaternized sugar 0.05-7.5 Foam Reinforcing Surfactant 0.2-5 Dermal adjuvants 0.1-7
    TABLE 12 [0105] Table 13 (Antimicrobial Effectiveness of a Surgical Pad of the Present Invention): Applicants tested the effectiveness of the surgical pad of the present invention by determining the logarithm of the reduction of gram positive and gram negative bacteria after 30 seconds of exposure.
    [0106] Surgical pad of the present invention (pH 5.5-7.5).
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    Component Weight percentage range Water 56-97.8 Cationic active substance (composed ofquaternary ammonium) 1-6 Surfactant derived from quaternized sugar 0.2 - 8 Foam Reinforcing Surfactant 0.5 - 10 Dermal adjuvants 0.5 - 20
    TABLE 13 [0107] The antimicrobial compositions of the present invention have several final practical uses, including hand cleaning products, surgical scouring pads, hand sanitizing gels and similar personal care products. Additional types of compositions include foamed compositions, such as creams, mousses and the like. The present antimicrobial compositions can be manufactured as diluted ready-to-use compositions or as concentrates that are diluted before use.
    [0108] Obviously, many modifications and variations of the invention as previously established can be made without departing from the spirit and scope of the same and, therefore, only such limitations should be imposed as indicated by the appended claims.
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    权利要求:
    Claims (7)
    [1]
    1. Foam-reinforcing antimicrobial skin cleanser, FEATURED by understanding:
    (a) between about 0.3% by weight and about 5% by weight of a compound containing quaternary ammonium;
    (b) between about 0.05% by weight and about 7.5% by weight of a surfactant derived from quaternized sugar which is a polyquaternized alkyl polyglycoside of formula:
    R
    ILjC — N— Í.U 3 where n is an integer ranging from 4 to 6, or a polyquaternized alkyl polyglycoside of the formula:
    where n is the degree of polymerization of 1-2, where R of the alkyl polyglycoside
    Petition 870180029999, of 04/13/2018, p. 43/53
    [2]
    2/3 polyquaternized is an alkyl group with about 6 to about 22 carbon atoms and where R1 of the polyquaternized alkyl polyglycoside is an alkyl group with about
    6 to about 22 carbon atoms, and R2 of the quaternized alkyl polyglycoside is
    CH3 (CH2) x, where x is an integer ranging from 0 to 21;
    (c) between about 0.2% by weight and about 6% by weight of a foam reinforcing surfactant, comprising an alkylamine oxide, alkyl ether oxide, or mixtures thereof; and (d) between about 7.5% by weight and about 99.3% by weight of water;
    wherein the relative weight ratio of compound containing quaternary ammonium to surfactant derived from quaternized sugar to foam reinforcing surfactant is from about 1: 0.2: 0.2 to about 1: 3: 8;
    where the composition does not contain anionic surfactants;
    where the composition exhibits deadly activity;
    wherein the composition is free of triclosan (2,4,4 ”-trichloro-2” -hydroxydiphenylether).
    2. Antimicrobial composition according to claim 1, CHARACTERIZED by the fact that the compound containing quaternary ammonium is between about 0.5% by weight to about 5% by weight of the composition.
    [3]
    3. Antimicrobial composition, according to claim 1, CHARACTERIZED by the fact that it also comprises phospholipids, phospholipids, amphoteric surfactants or mixtures thereof.
    [4]
    4. Antimicrobial composition according to claim 1, CHARACTERIZED by the fact that the composition has a pH range of about 4.0 to about 9.0.
    [5]
    5. Antimicrobial composition according to claim 1, CHARACTERIZED by the fact that the composition further comprises about 1% by weight to about 25% by weight of adjuvants.
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    [6]
    6. Antimicrobial composition, according to claim 1, CHARACTERIZED by the fact that the composition provides a logarithmic reduction in bacteria greater than 5 in 30 seconds.
    [7]
    7. Antimicrobial composition, according to claim 1, CHARACTERIZED by the fact that the composition provides compatibility with the skin and skin health.
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    Φ
    V-
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    法律状态:
    2018-01-16| B15K| Others concerning applications: alteration of classification|Ipc: A61K 8/40 (2006.01), A01N 25/16 (1980.01), A01N 25 |
    2018-01-16| B06A| Patent application procedure suspended [chapter 6.1 patent gazette]|
    2018-05-02| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2018-07-10| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|
    优先权:
    申请号 | 申请日 | 专利标题
    US38534110P| true| 2010-09-22|2010-09-22|
    US61/385,341|2010-09-22|
    PCT/IB2011/054157|WO2012038914A2|2010-09-22|2011-09-22|Antimicrobial compositions containing cationic active ingredients and quaternary sugar derived surfactants|
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